Acute Myeloid Leukemia in a Child with Fanconi Anemia-A Case Report from a Tertiary Care Cancer Center in South India

Case report: In an eight-year-old boy who was diagnosed with FA seven months back, blast cells in peripheral blood were detected following a respiratory illness. Physical examination revealed polydactyly, hyperpigmentation of the tongue, café au lait macules and hepatosplenomegaly. Bone marrow morphology and flow cytometry were performed, which suggested the diagnosis of AML M4. After providing initial supportive measures, induction chemotherapy was started with Daunorubicin and Cytarabine. After induction, febrile neutropenia ensued, which was treated with multiple antibiotics and supportive measures. Despite these efforts, the child succumbed one month after starting chemotherapy.